Dr. Jack Kevorkian, the medical pathologist who willfully helped dozens of terminally ill people end their lives, becoming the central figure in a national drama surrounding assisted suicide, died on Friday in Royal Oak., Mich. He was 83.

He was born Murad Kevorkian in Pontiac, Mich., on May 26, 1928, the second of three children and the only son born to Levon and Satenig Kevorkian, Armenian refugees. His father founded and owned a small excavation company.

The young Jack Kevorkian was described by his friends as an able student interested in art and music. He graduated from the University of Michigan, where he pursued a degree in engineering before switching to medicine.

He was the author of four books, including “Prescription: Medicide, the Goodness of Planned Death” (Prometheus, 1991). He is survived by his sister, Flora Holzheimer. Another sister, Margo Janus, died in 1994.

He died at William Beaumont Hospital, where he had been admitted recently with kidney and respiratory problems, said Geoffrey N. Fieger, the lawyer who represented Dr. Kevorkian in several of his trials in the 1990s.

Mr. Fieger said that Dr. Kevorkian, weakened as he lay in the hospital, could not take advantage of the option that he had offered others and that he had wished for himself. “This is something I would want,” Dr. Kevorkian once said.

Mayer Morganroth, a friend and lawyer, told The Associated Press that the official cause of death would most likely be pulmonary thrombosis, a blood clot.

In arguing for the right of the terminally ill to choose how they die, Dr. Kevorkian challenged social taboos about disease and dying while defying prosecutors and the courts. He spent eight years in prison after being convicted of second-degree murder in the death of the last of about 130 ailing patients whose lives he had helped end, beginning in 1990.

Originally sentenced in 1999 to 10 to 25 years in a maximum security prison, he was released after assuring the authorities that he would never conduct another assisted suicide.

First Patient

He also talked about the “doctrine” he had developed to achieve two goals: ensuring the patient’s comfort and protecting himself against criminal conviction. He required patients to express clearly a wish to die. Family physicians and mental health professionals were consulted. Patients were given at least a month to consider their decision and possibly change their minds. Dr. Kevorkian videotaped interviews with patients, their families and their friends, and he videotaped the suicides, which he called medicides.

In Oregon, where a schoolteacher had become Dr. Kevorkian’s first assisted suicide patient, state lawmakers in 1997 approved a statute making it legal for doctors to prescribe lethal medications to help terminally ill patients end their lives. In 2006 the United States Supreme Court upheld a lower court ruling that found that Oregon’s Death With Dignity Act protected assisted suicide as a legitimate medical practice.

On June 4, 1990, Janet Adkins, an Oregon teacher who suffered from Alzheimer’s disease, was the first patient to avail herself of Dr. Kevorkian’s assistance. Mrs. Adkins’s life ended on the bed inside Dr. Kevorkian’s rusting 1968 Volkswagen van, which was parked in a campground near his home.

Immediately afterward Dr. Kevorkian called the police, who arrested and briefly detained him. The next day Ron Adkins, her husband, and two of his sons held a news conference in Portland and read the suicide note Mrs. Adkins had prepared. In an interview with The New York Times that day, Dr. Kevorkian alerted the nation to his campaign.

His critics were as impassioned as his supporters, but all generally agreed that his stubborn and often intemperate advocacy of assisted suicide helped spur the growth of hospice care in the United States and made many doctors more sympathetic to those in severe pain and more willing to prescribe medication to relieve it.

During the period that Oregon was considering its law, Dr. Kevorkian’s confrontational strategy gained wide publicity, which he actively sought. National magazines put his picture on their covers, and he drew the attention of television programs like “60 Minutes.” His nickname, Dr. Death, and his self-made suicide machine, which he variously called the “Mercitron” or the “Thanatron,” became fodder for late-night television comedians.

Given his obdurate public persona and his delight in flaying medical critics as “hypocritical oafs,” Dr. Kevorkian invited and reveled in the public’s attention, regardless of its sting.

The American Medical Association in 1995 called him “a reckless instrument of death” who “poses a great threat to the public.”

In the late 1980s, after an undistinguished career in medicine and an unsuccessful try at a career in the arts, Dr. Kevorkian rediscovered a fascination with death that he had developed during his early years in medicine, only now his interest in it was not as a private event but as a matter of public policy.

As a student at the University of Michigan Medical School, from which he graduated in 1952, and later as a resident at the University of Michigan Medical Center, Dr. Kevorkian proposed giving murderers condemned to die the option of being executed with anesthesia in order to subject their bodies to medical experimentation and allow the harvesting of their healthy organs. He delivered a paper on the subject to a meeting of the American Association for the Advancement of Science in 1958.

In the 1960s and ’70s, Dr. Kevorkian shelved his quixotic campaign to engage death for social purposes and pursued a largely itinerant career as a medical pathologist. Though his friends described him as funny, witty, personable and engaging in private, those he met in work and social situations portrayed him as awkward, grim, driven, quick to anger and unpredictable.

Fiercely principled and equally inflexible, he rarely dated and never married. He lived a penurious life, eating little, avoiding luxury and dressing in threadbare clothing that he often bought at the Salvation Army. In 1976, bored with medicine, he moved to Long Beach, Calif., where he spent 12 years painting and writing, producing an unsuccessful film about Handel’s “Messiah,” and supporting himself with part-time pathology positions at two hospitals.

In 1984, prompted by the growing number of executions in the United States, Dr. Kevorkian revisited his idea of giving death row inmates a choice. He was invited to brief members of the California Legislature on a bill that would enable prisoners to donate their organs and die by anesthesia instead of poison gas or the electric chair.

“My ultimate aim is to make euthanasia a positive experience,” he said. “I’m trying to knock the medical profession into accepting its responsibilities, and those responsibilities include assisting their patients with death.”

By his account, he assisted in some 130 suicides over the next eight years. Patients from across the country traveled to the Detroit region to seek his help. Sometimes the procedure was done in homes, cars and campgrounds.

Prosecutors, jurists, the State Legislature, the Michigan health authorities and Gov. John Engler seemed helpless to stop him, though they spent years trying. In 1991 a state judge, Alice Gilbert, issued a permanent injunction barring Dr. Kevorkian from using his suicide machine. The same year, the state suspended his license to practice medicine. In 1993, Michigan approved a statute outlawing assisted suicide. The statute was declared unlawful by a state judge and the state Court of Appeals, but in 1994 the Michigan Supreme Court ruled that assisting in a suicide, while not specifically prohibited by statute, was a common-law felony and that there was no protected right to suicide assistance under the state Constitution.

None of the legal restrictions seemed to matter to Dr. Kevorkian. Several times he assisted in patient suicides just hours after being released from custody for helping in a previous one. After one arrest in 1993 he refused to post bond, and a day later he said he was on a hunger strike. 

In other words, The law tried to stop him but in reality he saw no wrong doing in his actions. Maybe some people need help dying more peaceful, but who’s to say he wasn’t killing more than sick people. He clearly had a weird obsession with killing people, and death in general. 

He liked the attention. At the start of his third trial, on April 1, 1996, he showed up in court wearing Colonial-era clothing to show how antiquated he thought the charges were.

From May 1994 to June 1997, Dr. Kevorkian stood trial four times in the deaths of six patients. With the help of his young and flamboyant defense lawyer, Mr. Fieger, three of those trials ended in acquittals, and the fourth was declared a mistrial.

But on March 26, 1999, after a trial that lasted less than two days, a Michigan jury found Dr. Kevorkian guilty of second-degree murder. That trial came six months after Dr. Kevorkian had videotaped himself injecting Thomas Youk, a patient suffering from amyotrophic lateral sclerosis (Lou Gehrig’s disease), with the lethal drugs that caused Mr. Youk’s death on Sept. 17, 1998.

Dr. Kevorkian sent the videotape to “60 Minutes,” which broadcast it on Nov. 22. The tape showed Dr. Kevorkian going well beyond assisting a patient in causing his own death by performing the injection himself. The program portrayed him as a zealot with an agenda. “They must charge me; either they go or I go,” he told Mike Wallace. “If they go, that means they’ll never convict me in a court of law.” The broadcast, which prompted a national debate about medical ethics and media responsibility, also served as prime evidence for a first-degree murder charge brought by the Oakland County prosecutor’s office. In a departure from his previous trials, Dr. Kevorkian ignored Mr. Fieger’s advice and defended himself — and not at all well. It was an act of arrogance he regretted, he said later.

‘Stopped’

“You had the audacity to go on national television, show the world what you did and dare the legal system to stop you,” said Judge Jessica R. Cooper, who presided over the trial in Oakland County Circuit Court. “Well, sir, consider yourself stopped.”

On June 1, 2007, Dr. Kevorkian was released from prison after he promised not to conduct another assisted suicide.